osteoarthritis caused by deterioration of the cartilage in the knee joint uneven knee surface causing pain due to friction of the bone From research both at home and abroad, many foreign journals have been published. Mesenchymal Stem Cells (MSCs) were used. To help create new cells to replace and can secrete anti-inflammatory substances. The alleviation of degenerative symptoms was quite good. Increase bone strength can reduce the use of painkillers. including knee replacement surgery Help extend the working life of the knee joint to stay with us forever. Reduce future knee replacement surgeries.